Antiparasitic indole alkaloids from Aspidosperma desmanthum and A. spruceanum from the Peruvian Amazonia

Matías Reina, Lastenia Ruiz-Mesia, Wilfredo Ruiz-Mesia, Frida Enriqueta Sosa-Amay, Leonor Arevalo-Encinas, Azucena González-Coloma, Rafael Martínez-Díaz

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12 Scopus citations

Abstract

Twenty-three indole alkaloids were isolated from Aspidosperma desmanthum and A. spruceanum. Alkaloids 1-4 were isolated from the leaves, 5-8 from the stem bark and 9 -15 from the root bark of A. desmanthum. Alkaloids 5, 11, 16, 17 and 19 were isolated from the stem bark, 18 and 20 -22 from the root bark and 23 from the flowers of A. spruceanum. Compounds 4, 14, and 15 have not been previously reported as natural products while 16 and 20 have been isolated for the first time from the genus Aspidosperma. Their structures were determined by spectroscopic techniques including 1D and 2D NMR experiments (COSY, NOESY, HSQC, HMBC). The antiparasitic activity of these compounds was tested against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity on mammalian cells. The most active compounds were 10, 12, 13, and 14 from A. desmanthum, and 19, 21 and 22 from A. spruceanum. Aspidolimine (10) aspidocarpine (12) and tubotaiwine (21) showed selective activity against L. infantum.

Original languageEnglish
Pages (from-to)1075-1080
Number of pages6
JournalNatural Product Communications
Volume9
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • A. spruceanum (Apocynaceae)
  • Antiparasitic activity
  • Aspidosperma desmanthum
  • Indole alkaloids

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