Infections au second trimestre par Trichuris et l'ankylostome, associées à l'anémie au troisième trimestre dans une population de femmes enceintes péruviennes

Translated title of the contribution: Trichuris and hookworm infections associated with anaemia during pregnancy

Theresa W. Gyorkos, Nicolas L. Gilbert, Renée Larocque, Martín Casapía

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Objective To assess the following associations between the second and third trimesters of pregnancy: (i) the intensity of soil-transmitted helminth (STH) infection and haemoglobin/anaemia, (ii) the effect of mebendazole treatment on the occurrence of STH infection, and (iii) the effect of mebendazole treatment on haemoglobin/anaemia. Methods Data originated from a trial of 1042 pregnant women recruited in their second trimester and followed to delivery. Baseline assessments included socio-demographic/health information from questionnaires, haemoglobin/anaemia from HemoCue ascertainment of fingerprick blood, and the presence and intensity of STH (Ascaris lumbricoides, hookworms and Trichuris trichiura) infections from Kato-Katz examination. All women were given iron supplements; half were randomly allocated to receive single dose 500mg mebendazole, and half, placebo. Haemoglobin/anaemia and STH infection status were determined again in the third trimester of pregnancy. Results Complete information was available from 935 (89.7%) women. Mebendazole significantly reduced the prevalence and intensity of all three STH infections. Higher intensities of hookworm and Trichuris infections in the second trimester were associated with a higher risk of anaemia in the third trimester. Overall, women with moderate/heavy Trichuris infection were found to be at a higher risk of anaemia; the highest risk was observed among those with moderate/heavy hookworm co-infection (adjusted OR=2.77; 95% CI: 1.26, 6.11). Mebendazole treatment did not reduce the risk of anaemia. Conclusion Higher intensities of both Trichuris and hookworm infections are associated with anaemia in pregnancy. The importance of Trichuris infections during pregnancy requires renewed attention.

Translated title of the contributionTrichuris and hookworm infections associated with anaemia during pregnancy
Original languageFrench
Pages (from-to)531-537
Number of pages7
JournalTropical Medicine and International Health
Volume16
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • Anaemia
  • Ascaris lumbricoides
  • Haemoglobin
  • Hookworms
  • Pregnancy
  • Soil-transmitted helminths
  • Trichuris trichiura

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