TY - JOUR
T1 - HEMATOLOGICAL PROFILES OF MALARIA-INFECTED PATIENTS IN AN ENDEMIC AREA OF PERU
AU - Pinedo-Cancino, Viviana
AU - Arista Flores, Katty Madeleine
AU - Valle-Campos, Andree
AU - Saavedra-Langer, Rafael
AU - Roca, Cristian
AU - Ramos-Rincón, José Manuel
AU - Calderón, Maritza
AU - Branch, Oralee H.
N1 - Publisher Copyright:
© 2022, Instituto Nacional de Salud. All rights reserved.
PY - 2022/9/30
Y1 - 2022/9/30
N2 - Objectives. To evaluate the variation of hematological profiles of patients infected with uncomplicated Plasmodium vivax (Pv) and P. falciparum (Pf) malaria before, during and after treatment in a population of the Loreto region. Materials and methods. This study was conducted between 2010 and 2012, in Zungarococha (Iquitos). The 425 participants had three visits (visit 1-day 0-before treatment, visit 2-day 7-during treatment, visit 3-day 28-after treat-ment), complete blood count, microscopic and mole-cular diagnosis (PCR). Results. At the first visit, 93 (21.9%) participants were found positive for Pv and 34 (8.0%) for Pf. All positives showed a reduction in hematocrit, white blood cell count (WBC), ablated and segmented neutrophils, eosinophils and platelets (p<0.001) compared to the negative group. A higher percentage of ablated neutrophils was found in Pf and segmented neutrophils in Pv com-pared to the negative group. Variations in hematological profiles were observed after treatment for both species; ablated neutrophils decreased, platelets increased, eosinophils increased at day 7 and declined at day 28, hematocrit and segmented neutrophils decreased at day 7 and normalized at day 28. Interspecies differences over time showed a bigger daily decrease in ablated neutrophils in Pv-infected when compared to Pf. Conclusions. The hematological profile in uncomplicated malaria-positive patients varies over time during and after treatment. These are indicators of disease progression and help in the therapeutic surveillance of Plasmodium-infected patients.
AB - Objectives. To evaluate the variation of hematological profiles of patients infected with uncomplicated Plasmodium vivax (Pv) and P. falciparum (Pf) malaria before, during and after treatment in a population of the Loreto region. Materials and methods. This study was conducted between 2010 and 2012, in Zungarococha (Iquitos). The 425 participants had three visits (visit 1-day 0-before treatment, visit 2-day 7-during treatment, visit 3-day 28-after treat-ment), complete blood count, microscopic and mole-cular diagnosis (PCR). Results. At the first visit, 93 (21.9%) participants were found positive for Pv and 34 (8.0%) for Pf. All positives showed a reduction in hematocrit, white blood cell count (WBC), ablated and segmented neutrophils, eosinophils and platelets (p<0.001) compared to the negative group. A higher percentage of ablated neutrophils was found in Pf and segmented neutrophils in Pv com-pared to the negative group. Variations in hematological profiles were observed after treatment for both species; ablated neutrophils decreased, platelets increased, eosinophils increased at day 7 and declined at day 28, hematocrit and segmented neutrophils decreased at day 7 and normalized at day 28. Interspecies differences over time showed a bigger daily decrease in ablated neutrophils in Pv-infected when compared to Pf. Conclusions. The hematological profile in uncomplicated malaria-positive patients varies over time during and after treatment. These are indicators of disease progression and help in the therapeutic surveillance of Plasmodium-infected patients.
KW - Blood Cell Count
KW - Parasites
KW - Peruvian Amazon
KW - Plasmodium
KW - Platelets
KW - Tropical Disease
UR - http://www.scopus.com/inward/record.url?scp=85142259478&partnerID=8YFLogxK
U2 - 10.17843/rpmesp.2022.393.11908
DO - 10.17843/rpmesp.2022.393.11908
M3 - Article
C2 - 36478167
AN - SCOPUS:85142259478
SN - 1726-4634
VL - 39
SP - 336
EP - 344
JO - Revista Peruana de Medicina Experimental y Salud Publica
JF - Revista Peruana de Medicina Experimental y Salud Publica
IS - 3
ER -