TY - JOUR
T1 - Indole alkaloids from Aspidosperma rigidum and A. schultesii and their antiparasitic effects
AU - Reina, Matías
AU - Ruiz-Mesia, Wilfredo
AU - Ruiz-Mesia, Lastenia
AU - Martínez-Díaz, Rafael
AU - González-Coloma, Azucena
PY - 2011
Y1 - 2011
N2 - Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identifi ed as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specifi c cytotoxicity against mammalian cells were also determined.
AB - Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identifi ed as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specifi c cytotoxicity against mammalian cells were also determined.
KW - Aspidosperma rigidum
KW - Aspidosperma schultesii
KW - Indole Alkaloids
UR - http://www.scopus.com/inward/record.url?scp=79959579795&partnerID=8YFLogxK
U2 - 10.1515/znc-2011-5-605
DO - 10.1515/znc-2011-5-605
M3 - Article
AN - SCOPUS:79959579795
SN - 0939-5075
VL - 66 C
SP - 225
EP - 234
JO - Zeitschrift fur Naturforschung - Section C Journal of Biosciences
JF - Zeitschrift fur Naturforschung - Section C Journal of Biosciences
IS - 5-6
ER -