TY - JOUR
T1 - Spatial patterns in discordant diagnostic test results for chagas disease
T2 - Links to transmission hotspots
AU - Levy, Michael Z.
AU - Bowman, Natalie M.
AU - Kawai, Vivian
AU - Plotkin, Joshua B.
AU - Waller, Lance A.
AU - Cabrera, Lilia
AU - Steurer, Frank
AU - Seitz, Amy E.
AU - Pinedo-Cancino, Viviana V.
AU - Carpio, Juan Geny Cornejo Del
AU - Benzaquen, Eleazar Cordova
AU - McKenzie, F. Ellis
AU - Maguire, James H.
AU - Gilman, Robert H.
AU - Bern, Caryn
N1 - Funding Information:
1Fogarty International Center, National Institutes of Health, Bethesda, and 2Johns Hopkins Hospital and 3Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland; 4Biology Department, University of Pennsylvania, Philadelphia; 5Program in Population Biology, Ecology, and Evolution, Division of Biological and Biomedical Sciences, Emory University, and 6Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; 7Division of Infectious Disease, Brigham and Women’s Hospital, Boston, Massachusetts; 8Asociación Benéfica Proyectos en Informática, Salud, Medicina y Agricultura (AB PRISMA), Lima, and 9Dirección Regional del Ministerio de Salud, Arequipa, Perú
Funding Information:
Financial support. National Institutes of Health (5P50AI074285-02, R01-ES015525, U19-AI-33061, RO1-AI047498; NIAID grant K01AI079162 to M.Z.L. and training grant 5T35AI007646-03 to N.M.B.), Fogarty/Ellison fellowship to N.M.B., the International Society for Infectious Diseases grant to V.K. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Potential conflicts of interest. All authors: no conflicts.
PY - 2009/4/15
Y1 - 2009/4/15
N2 - Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.
AB - Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.
UR - http://www.scopus.com/inward/record.url?scp=63649103891&partnerID=8YFLogxK
U2 - 10.1086/597464
DO - 10.1086/597464
M3 - Article
C2 - 19278335
AN - SCOPUS:63649103891
SN - 1058-4838
VL - 48
SP - 1104
EP - 1106
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 8
ER -
